Overview of the Computational Biochemistry and Biophysics Project

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The Project, born in 1991 and directed by Dr. Giorgina Corongiu, is strongly linked to the Computational Chemistry Project, directed by Prof. Enrico Clementi. The collaboration between the two Projects has its roots in the group created and directed by Clementi at IBM Kingston (NY).

The expertise of the CBB Project in the various fields of biochemistry, and in the study of the relationship between the structure of macromolecules (such as DNA, polypeptides, proteins, enzymes, etc.) and their biological and pharmaceutical activity is strong. In this field, we stress our researchers know-how in deriving from first principles, interactions and forces (force field) from the subunits which make up macromolecules and in carrying out simulations of biomolecules in vacuo, in solution and in crystalline structure.